Exhibit 99.1

 VEGA-1 Phase 2 Topline Results Conference Call  June 30, 2021 

 Disclosures and Forward Looking Statements   This presentation contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements include, but are not limited to, statements concerning Ocuphire Pharma, Inc.’s (“Ocuphire” or the “Company”) product candidates and future milestones, including the potential for Nyxol to be a “best in class” presbyopia drop.  These forward-looking statements are based upon the Company’s current expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, including, without limitation: (i) timing or ability for the company to achieve its targeted milestones; (ii) the success and timing of regulatory submissions and pre-clinical and clinical trials; (iii) regulatory requirements or developments; (iv) changes to clinical trial designs and regulatory pathways; (v) changes in capital resource requirements; (vi) risks related to the inability of the Company to obtain sufficient additional capital to continue to advance its product candidates and its preclinical programs; (vii) legislative, regulatory, political and economic developments, and (viii) the effects of COVID-19 on clinical programs and business operations. The foregoing review of important factors that could cause actual events to differ from expectations should not be construed as exhaustive and should be read in conjunction with statements that are included herein and elsewhere, including the risk factors detailed in documents that have been and may be filed by the Company from time to time with the SEC. All forward-looking statements contained in this presentation speak only as of the date on which they were made. The Company undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.  The Company makes no representation or warranty, express or implied, as to the accuracy or completeness of the information contained in or incorporated by reference into this presentation.  Nothing contained in or incorporated by reference into this presentation is, or shall be relied upon as, a promise or representation by the Company as to the past or future.  The Company assumes no responsibility for the accuracy or completeness of any such information. This presentation  may not be reproduced or provided to any other person (other than your advisor) without our prior written consent.  By accepting delivery of this presentation, you agree to the foregoing and agree to return this presentation and any documents related thereto and any copies thereof to us or to destroy the same if you do not make an investment in any securities. The information contain within this presentation shall not, except as hereinafter provided, without the prior written consent of the Company, be disclosed by you or your representatives in any manner whatsoever, in whole or in part, and shall not be used by you or your representatives other than for the purpose of evaluating the transaction described herein.  By accepting delivery of this presentation you further acknowledge and agree aware of the restrictions imposed by the United States securities laws on the purchase or sale of securities by any person who has received material, nonpublic information from the issuer of the securities or any affiliate thereof and on the communication of such information to any other person when it is reasonably foreseeable that such other person is likely to purchase or sell such securities in reliance on such information for so long as the information remains material and non-public. This presentation also contains estimates and other statistical data made by independent parties and by us relating to market shares and other data about our industry. This data involves a number of assumptions and limitations, and you are cautioned not to give undue weight to such estimates.  The trademarks included herein are the property of the owners thereof and are used for reference purposes only. Such use should not be construed as an endorsement of such products.   November 6, 2020 

 Agenda and Participants  Topline VEGA-1 Phase 2 Clinical Trial Results for Nyxol and Low-Dose Pilocarpine in PresbyopiaPresbyopia Market OpportunityFuture MilestonesQ&AParticipantsMina Sooch, MBA, President and CEOMitch Brigell, PhD, Head of Clinical DevelopmentJay Pepose, MD, Medical Advisory Board & Corporate Board MemberSusan Benton, Corporate Board MemberCharlie Hoffmann, MBA, VP of Corporate Development and OperationsAmy Rabourn, MAcc, VP of Finance    Phase 2 Trial Topline Readout As Planned In 2Q21 

   Product Candidate  Indication  Development Stage        Anticipated Milestones        Pre-clinical  Phase 1  Phase 2  Phase 3    Ocuphire-Focused Development  0.75% Nyxol®Eye Drop  Reversal of Mydriasis (RM)           Initiated Phase 3 MIRA-2 trial 4Q20; Topline data reported in 1Q21 (n=185)Initiate Phase 3 MIRA-3 trial 2H21; Data expected in early 2022 (n=330) Initiate Pediatric trial 2H21;Data expected in early 2022 (n=20)     0.75% Nyxol®Eye Drop  Dim Light or Night Vision Disturbances (NVD)          Initiated Phase 3 LYNX-1 trial 4Q20;Data expected in 3Q21 (n=160)    0.75% Nyxol® + Low-Dose 0.4% Pilocarpine Eye Drops  Presbyopia (P)          Initiated Phase 2 VEGA-1 trial 1Q21;Topline data reported in 2Q21 (n=150)    APX3330 Oral Pill  Diabetic Retinopathy (DR)/ Macular Edema (DME)          Initiated Phase 2 ZETA-1 trial Apr21;Data expected by early 2022 (n=100)  Partnering-Focused Development  APX2009 Intravitreal  DME, Wet Age-Related Macular Degeneration (wAMD)          Next steps: IND enabling studies  (with partner funding)    Ocuphire Pipeline & Upcoming Milestones    Multiple Phase 3 & Phase 2 Clinical Data Readouts Anticipated Over The Next Year  Note: 0.75% Nyxol (Phentolamine Ophthalmic Solution) is the same as 1% Nyxol (Phentolamine Mesylate Ophthalmic Solution)   Positive Data Readout    Positive Data Readout           

 Product Profile: Nyxol + Low-Dose Pilocarpine (LDP) Combo  Moderate Use of Iris Dilator And Iris Sphincter Muscles To Improve Near Vision  0.4%            0.75%Nyxol  0.4% LDP        Nyxol  LDP    P  Iris Dilator Muscle Inhibition  Iris Sphincter Muscle Activation      Active ingredient approved decades ago 505(b)(2)Novel MOA on iris dilator with 24+ hour durability with moderate 1+mm pupil reductionChronic daily dosing of Nyxol at bedtime demonstrated no daytime rednessWell-tolerated with no systemic effectsStable, preservative-free, single use vial  Active ingredient approved decades ago 505(b)(2)Known MOA on sphincter muscle with more potent miotic effects at approved doses (1%, 2%, 4%)Chronic daily dosing in daytimeLow concentration avoids known tolerability issues:headache and browacherednessaccommodative spasm causing loss of distance vision especially at night  Source: Ocuphire Clinical Trials (completed) 

 Potential ‘Best in Class’ Presbyopia DropTopline Results From Vega-1 Were Positive…    Nyxol + LDP Presbyopia Treatment is Differentiated: Statistically significant efficacy dataFavorable safety profileComfort and tolerabilityFast onsetLong durationMaintain good distance visual acuity (night/day)Novel tunable pupil modulation   P 

   Nyxol®  Phentolamine Mesylate  NVD    P  Presbyopia  RM  Night Vision Disturbances  Reversal of Mydriasis  0.4%            + 

 Topline VEGA-1 Phase 2 Results  Randomized, Multi-Center, Double-Masked, Placebo-Controlled Study of the Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) + 0.4% Low Dose Pilocarpine (LDP) for the Treatment of Presbyopia  Clinical trial NCT#04675151 

 Objectives and Key Eligibility Criteria  Key ObjectivesPRIMARYTo evaluate the efficacy of Nyxol + LDP to improve DCNVA compared to Placebo alone in presbyopia subjectsKEY SECONDARYTo evaluate the ocular and systemic safety of Nyxol + LDP and each component individuallyTo evaluate multiple secondary visual acuity and pupil diameter endpoints  Clinical trial NCT#04675151. BCDVA is Best Corrected Distance Visual Acuity and DCNVA is Distance Corrected Near Visual Acuity  VEGA-1 (OPI-NYXP-201) Phase 2 Trial Evaluating Nyxol + LDP for Treatment of Presbyopia  Key Eligibility CriteriaINCLUSIONMales or females ≥ 40 and ≤ 64 years of age.BCDVA of 20/20 or better under photopic conditionsDCNVA of 20/50 or worse under photopic conditionsBinocular best-corrected near VA is 20/25 or better EXCLUSIONClinically significant ocular diseaseRecent or current evidence of ocular infection or inflammation in either eye  P 

 Presbyopia VEGA-1 Phase 2 Design  Clinical trial NCT#04675151  Randomized, Double-Masked, Placebo-Controlled One-Week Trial  Primary: % of subjects with ≥ 3 lines of improvement in distance-corrected near visual acuity comparing Nyxol + LDP vs placebo alone at 1 hourSecondary:% of subjects with ≥ 2 and ≥ 3 lines gained at time points from 30 min to 6 hours in photopic and mesopic lighting comparing Nyxol + LDP vs placebo, Nyxol alone, and LDP aloneNo loss of distance vision Pupil diameter at time pointsSafety and tolerability (redness)  Endpoints  P  Phase 2 Enrollment Completed Feb to May 2021 – 150 SubjectsReporting Topline Results as Guided by End of 2Q21  Visit 1    VEGA-1  Randomization  4 arms  0.75% Nyxol   Placebo  17 US sites150 presbyopic patients  Visit 2 (3 – 6 Days Later)  Screening  Treatment Arms  Nyxol + LDP  LDP Drop  Nyxol  Baseline  Nyxol Alone  No Treatment  Nyxol  Baseline  LDP Alone  LDP Drop  Placebo   Baseline  Placebo Alone  No Treatment  Placebo   Baseline  Evening Dosing(3-4 doses) 

 Patient Population – Subject Disposition  148/150 subjects completed the study (mITT)Only a single subject difference between mITT and PP populationPer Statistical Analysis Plan, all analyses performed on PP population with results being nearly identical for mITT  Source: VEGA-1 TLR Table 14.1.1 Subject Disposition   Per Protocol Population, mITT, And Safety Population Are Essentially Identical    Placebo Alone N (%)   Nyxol Alone N (%)  LDP Alone N (%)  Nyxol+LDP N (%)  Total N (%)              All Randomized Population (ARP)  45  30  31  44  150  Safety Population (SP)  45 (100%)  30 (100%)  31 (100%)  44 (100%)  150 (100%)  Modified Intention to Treat Population (mITT)  44 (98%)  30 (100%)  31 (100%)  43 (98%)  148 (99%)  Per Protocol Population (PP)  43 (96%)  30 (100%)  31 (100%)  43 (98%)  147 (98%)  Completed Study  44 (98%)  30 (100%)  31 (100%)  43 (98%)  148 (99%)  Discontinued Study Early  1 (2%)  0  0  1 (2%)  2 (1%)  P 

 Demographics (PP Population)  Treatment And Placebo Arms Were Balanced In This Phase 2 Clinical Trial  Source: VEGA-1 TLR Table Demographics and Baseline Characteristics (PP Population)  P    Placebo Alone N=43  Nyxol Alone N=30  LDP Alone N=31  Nyxol+LDP N=43  Total N=147              Age (years): Median (Range)  52 (42-62)  54 (41-60)  52 (44-64)  53 (43-63)  53 (41-64)  Sex: Male n (%) Female n (%)  15 (35%)28 (65%)  7 (23%)23 (77%)  13 (42%)18 (58%)  5 (12%)38 (88%)  40 (27%)107 (73%)  Race: White n (%)African American n (%)Asian n (%)Other* n (%)  37 (86%)4 (9%)2 (5%)0 (0%)  26 (87%)0 (0%)0 (0%)1 (3%)  28 (90%)1 (3%)6 (6%)1 (3%)  40 (93%)0 (0%)6 (6%)0 (0%)  131 (89%)3 (2%)11 (5%)2 (1%)  Dark Iris Color: n (%)  18 (42%)  12 (40%)  12 (39%)  18 (42%)  60 (41%)  Light Iris Color: n (%)  25 (58%)  18 (60%)  19 (61%)  25.1 (58%)  87 (59%)  * includes American Indian or Alaska Native; Native Hawaiian or Other Pacific Islander 

 Baseline Characteristics Study Eye (PP Population)    Placebo Alone N=43  Nyxol AloneN=30  LDP Alone N=31  Nyxol+LDPN=43  TotalN=147  Baseline Characteristic            Photopic DCNVA Mean Letters read-Binocular (Snellen Equiv.)70 letters = 20/20   46 (20/63)  45 (20/63)  48(20/63)  46 (20/63)  46 (20/63)  Photopic BCDVA Mean Letters read-Binocular (Snellen Equiv.)55 letters = 20/20  62 (20/15)  61 (20/15)  60 (20/15)  61 (20/15)  61(20/15)  Photopic Pupil Diameter Mean (mm)  4.3  4.5  4.3  4.3  4.3  Mesopic Pupil Diameter Mean (mm)  5.1  5.0  5.0  5.1  5.1  IOP (mmHg)  13.5  14.8  13.9  14.4  14.1  Treatment Arms Were Balanced Across Key Ocular Measurements  Source: VEGA-1 TLR Table Demographics and Baseline Characteristics (PP population). Snellen Conversion Chart.  P 

   Primary Endpoint: % of Subjects ≥ 15 Letter Gain in Photopic DCNVA at 1 Hour  Primary Endpoint Was Met For Nyxol + LDP Gaining ≥ 15 Letters Near Vision In PP Population  VEGA-1 Phase 2 Trial  P  Source: VEGA-1 TLR Table (mITT) and (PP)Percent of Subjects With Improvement From Baseline in Photopic DCNVA by Time Point . 15 letters is 3 lines.  p=0.003  34% Placebo Adjusted Responders   

 Secondary Endpoint: % of Subjects ≥ 10 Letter Gain In Photopic DCNVA At 1 Hour  Source: VEGA-1 TLR Table (mITT) and (PP) Percent of Subjects With Improvement From Baseline in Photopic DCNVA by Time Point. 10 letters is 2 lines.  Many Subjects Treated With Nyxol + LDP Gained A Clinically Meaningful ≥ 10 Letters     VEGA-1 Phase 2 Trial  P  p=0.006  p=0.007  30%Placebo Adjusted Responders  29%Placebo Adjusted Responders     

 Secondary Endpoint: % of Subjects ≥ 15 Letter Gain At All Timepoints  Source: VEGA-1 TLR Table Percent of Subjects with Improvement From Baseline in Photopic DCNVA by Time Point (PP Population). 15 letters is 3 lines.  Nyxol + LDP Had Strong Response With ≥ 15 Letter Gain From 30 Min To 6 Hours  P      Durable benefit over 6 hours  Rapid onset of efficacy      VEGA-1 Phase 2 Trial 

 Source: VEGA-1 TLR Table Percent of Subjects With Improvement From Baseline in Photopic DCNVA by Time Point (PP Population)   Similar Results Were Seen Monocularly For Study Eye And Fellow Eye On Primary Endpoint  Secondary Endpoint: % of Subjects ≥ 15 Letter Gain DCNVA (Monocular)    P    VEGA-1 Phase 2 Trial   

 2nd Endpoint: % of Subjects ≥ 15 Letter Gain In Near & ≤ 5 Letter Loss In Distance  Source: VEGA-1 TLR Table Percent of Subjects with >= 15 Letters of Improvement in Photopic DCNVA and < 5 Letters of Loss in Photopic Binocular BCDVA by Time Point (PP Population)  Phase 3 Approval Endpoint Also Showed Early Onset Of Near Vision Gain Without Loss of Distance   P  p=0.0009  Statistics Compared to Nyxol+LDP armPowered for comparison to placebo whereas comparison to component arms were designed to inform the Phase 3 sample size    VEGA-1 Phase 2 Trial   

 Change in Photopic and Mesopic BCDVA at the 1-Hour Timepoint  Source: VEGA-1 TLR Table and Percent of Subjects With Improvement or Loss From Baseline in Photopic and Mesopic BCDVA by Time Point (PP)   Treatment With Nyxol And/Or LDP Did Not Reduce BCDVA And Had A Modest Beneficial Effect  P        VEGA-1 Phase 2 Trial 

 Secondary Endpoint: Mean Pupil Diameter Over Time  Source: VEGA-1 TLR Table Observed Values and Change from Baseline in Photopic Pupil Diameter by Time Point (PP Population)   Achieved Pupil Size ~2mm In Nyxol+LDP Consistent With 3-line Improvement In Near Vision  P  Statistics Compared to Nyxol+LDP arm   *p<0.05**p<0.01***p<0.0001 

 Secondary Endpoint: Safety Findings   Source: VEGA-1 TLR Table Overall Summary of Treatment Emergent Adverse Events (TEAE) (Safety Population)Table Treatment-Emergent Adverse Events (TEAE) by System Organ Class, Preferred Term, and Severity (Safety Population)   Nyxol+LDP Combination Was Well Tolerated With A Favorable Safety Profile In VEGA-1 Trial   ​  Placebo Alonen=45  Nyxol Alonen=30  LDP Alonen=31  Nyxol+LDPn=44  Total Treatment Emergent Adverse Events (n)​  4  18  13  50  TEAEs by Severity (n [%])​Mild​Moderate​Severe​  ​1 (2.2%)​1 (2.2%)​0 (0%)​  6 (20%)​0 (0%)​0 (0%)​  6 (19.4%)​0 (0%)​0 (0%)​  ​13 (29.5%)​1 (2.3%)​1 (2.3%)​  AEs Occurring in ≥ 5% of subjects (n [%])​Instillation Site Pain (Mild)Instillation Site Erythema (Mild)​Conjunctival Hyperemia (Mild)Eye Disorders (Mild)​  ​1 (2.2%)​0 (0%)0 (0%)​1 (2.2%)  3 (10%)​3 (10%)2 (6.7%)​2 (6.7%)  0 (0%)​2 (6.5%)0 (0%)​4 (12.9%)  ​4 (9.1%)5 (11.4%)​2 (4.5%)​5 (11.4%)     No deaths, no serious AEs, and 1 withdrawal due to AEs (on Nyxol alone)0% Headaches or Browaches reported for Nyxol+LDP and Nyxol aloneOnly 1 subject in LDP alone arm reported mild headacheAlmost all AEs were mild and most common was mild instillation site discomfortDistance visual acuity not adversely affected (as shown earlier)No change in IOP    P 

 Tolerability: Conjunctival Hyperemia (Redness) Score  Source: VEGA-1 TLR Table Continuous Summary of Conjunctival Hyperemia by Time Point (Safety Population)     Minor Change (0.5 Point) In Redness Score Over The First 2 Hours In LDP Arms  P  Conjunctival Hyperemia CCLRU Scale for Reference 

 Summary of Positive VEGA-1 Phase 2 Results for Nyxol Eye Drops  Met the primary endpoint with statistical significance for binocular photopic near vision at 1 hour 61% Nyxol + LDP gained 15 letters (3 lines) or more vs. 28% Placebo (33% Placebo Adjusted)Met the Phase 3 co-primary endpoint vs. placebo gaining 15 letters (3 lines) near vision with less than 5 letters of distance vision lossMet many key secondary endpointsRapid onset at 30 minDurable near vision improvement through at least 6 hoursNyxol+LDP was numerically better than each component through 2-hoursSustained significant reduction in PD over at least 18 hours due the durability effects of NyxolNear vision efficacy seen monocularly and binocularlyAlso, efficacy data in both light and dark iris colorsFavorable safety profile for Nyxol + LDPNo serious AEsNo systemic AEs were observed in >5% subjectsNo headaches, no browaches, and no blurry vision AEs were reportedOnly mild, transient conjunctival hyperemia observed in <5% of subjectsPositive Phase 2 results lead to advancing Phase 3 presbyopia program  VEGA-1 Topline Reports (TLR)  Efficacy Data In Subjects With A Favorable Safety Profile In Presbyopia With Nyxol And Low Dose Pilocarpine  P 

 Next Steps  VEGA-1 Presbyopia Presentation by Dr. Pepose at ASCRS on Sunday July 25, 2021 at 8:45amASCRS Paper ID 76645 SPS-204 Presbyopia Correcting IOL Comparisons, New Treatments and StudiesMBCR - Level 2, Lagoon EFMIRA-2 Reversal of Mydriasis Presentation by Dr. Pepose at ASCRS on Monday July 26, 2021 at 4:25pmASCRS Paper ID 76599 SPS-316 Corneal Diagnostic StudiesMBCR - Level 2, Lagoon EF     Ocuphire Plans To Present Full Results At ASCRS In July And Move Into Phase 3  P  Advance into Phase 3 Presbyopia Registration Trials in 2022 Towards a Potential NDA in 2023 

 Presbyopia Market Opportunity 

 Presbyopia – Chronic Opportunity  Lens loses ability to change shape when viewing objects up close as we ageDependence on reading glasses for intermittent and prolonged useGrowing need for therapies that improve, rather than hinder, quality of life  Source: GlobalData Market Research Report, 2020  The Problem  Aging Population Drives Demand for Alternatives to Reading Glasses & Very Large Market  P  120 M Patients  No Currently Approved Drug Therapies  Effectively everyone over 40 will have the problems with reading.  Physician KOL      Seeking Treatment Findings    Patients requesting alternative to reading glasses  40%  Patients would consider an eye drop alternative  69%  ~$5B Market Opportunity 

 Presbyopia – Chronic Opportunity  “Pin-hole” effect of Nyxol and low dose pilocarpine may improve near vision by increasing depth of focus as validated by other devices/therapiesMore durable combination of two miotics affecting different muscles (iris dilator and sphincter) involved in pupil size modulationTolerable use with minimal side effects expected with chronic evening use of Nyxol  Retinaeyedoctor.com, GlobalData Market Research Report, 2020  Nyxol’s Potential Differentiated Solution  Pupil Modulation Eye Drops May Replace Reading Glasses    Large Pupil  Pin-hole Pupil  Near  Far  In focus  In focus  P  This would just become part of my daily routine for my eyes to be able to see things up close. How convenient is that?  Presbyopic Patient, age 49     

 Synergistic Effects of Nyxol + Low-Dose Pilocarpine (LDP) Combo  Source: Ocuphire Clinical Trials  Nyxol + LDP Demonstrated Efficacy and a Favorable Safety Profile in VEGA-1 Trial  Average PD in photopic conditions is 3.5 to 4.5 mm  1.5 to 2.5 mm PD reductionmoves toward the pin-hole (1.6 to 2.5 mm, up to <3 mm)  ~0.7 to 1+ mmReduction in PD1  ~1 to 1.5+ mmReduction in PD    Nyxol  LDP    P  Benefits of Nyxol + LDP: Observed longer durability of effect  inhibition of the dilator muscle with Nyxol may allow sphincter muscle to constrict without opposition and the long-acting effects of NyxolLower dose of pilocarpine showed a moderate miotic effect on sphincter muscleLower dose of pilocarpine showed reduced known side effects such as headaches, browaches, and day/night distance loss      ≥ 3-line improvement in near vision expected  0.4%            0.75%Nyxol  0.4% LDP      Iris Dilator Muscle Inhibition  Iris Sphincter Muscle Activation     

         Phase 3  Phase 2  Phase 1  Presbyopia Eye Drops Competitive Landscape  Corporate Websites, Grzybowski, A, Markeviciute A, Zemaitiene R. A Review of Pharmacological Presbyopia Treatment. 2020  Validation of Pupil Modulating Drops Achieving Pin-Hole Effect & Efficacy, Many with Pilocarpine  Pupil modulation MOA    Combination drugs      Soften lens MOA          Phase 3  Phase 2  Phase 1  Allergan(AGN-190584;1.25% pilo)      Orasis(CSF-1; Low dose pilo)    Ocuphire(0.75% Nyxol + 0.4% pilo)  Visus(Brimochol®; brimonidine + carbachol)  Other Cholinergic Agonists*  CholinergicAgonist* (pilocarpine)  Lenz(PRX-100; aceclidine)      Eyenovia(MicroLine;1 or 2% pilo)    Novartis(EV-06)  Alpha Antagonist& pilocarpine*  P    NDA  *act on sphincter and ciliary muscles in dose-dependent manner  Ocuphire is differentiated by using both the dilator and sphincter muscles moderately to reach a pin-hole pupil size 

 Potential ‘Best in Class’ Presbyopia DropCompetitive Approaches Limited by Safety/Tolerability, Durability, and Poor Distance Night Vision    Nyxol + LDP Presbyopia Treatment is Differentiated: Statistically significant efficacy dataFavorable safety profileComfort and tolerabilityFast onsetLong durationMaintain good distance visual acuity (night/day)Novel tunable pupil modulation   P 

 Future Milestones 

   2021 to 2022 Ocuphire Cadence of Milestones  Multiple Data Catalysts On Path To NDA(s)  Ongoing partnering discussions with leading ophthalmic companies (including European and Asian players)  Completion of APX3330 LicenseARVO 2020 Presentation for MIRA-1 & ORION-1FDA EOP2 Meeting May 2020Completion of Transaction (Nasdaq: OCUP) and concurrent $20M financingInitiate Phase 3 RM TrialInitiate Phase 3 NVD TrialComplete Nyxol Market ResearchJournal Publications  Enrollment of Phase 3 RM TrialInitiate Phase 2 Presbyopia TrialReport Positive Phase 3 Data for RMInitiate Phase 2 DR/DME TrialEnrollment of Phase 2 Presbyopia TrialNew Patent ClaimsClosed $15M registered direct offeringReport Positive Phase 2 Data for Presbyopia  ASCRS 2021 Presentation for MIRA-2 & VEGA-1Initiate 2nd P3 RM and Pediatric RM trial for NDA Enrollment of Phase 3 NVD TrialReport Phase 3 Data for NVDEnrollment of Phase 2 DR/DME TrialIndustry Conferences & PublicationsManufacture 3xRegistration Batches for Nyxol Blow-Fill-Seal (BFS) Eye DropsComplete 6-month Rabbit Tox Study  Report 2nd Ph3 RM Trial Report Pediatric RM trial Report Phase 2 Data for DR/DMEInitiate 2 Phase 3 Presbyopia TrialsInitiate Chronic Ph3 Safety Trial (Nyxol /LDP)Complete 1 year CMC stability on 3xreg batchesSubmit Nyxol NDA filing for RM in late 2022 Manufacture Commercial Batches of Nyxol Eye Drop  2020  1H 2021  2H 2021  2022*  2023*  Report Phase 3 Data for Presbyopia TrialsPotential NDA for Nyxol in RMPotential Commercial Launch of Nyxol in USSubmit NDA filing for Nyxol for Presbyopia in 2023  *Additional Studies for NVD and DR based on Data Readouts  P 

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